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KMID : 0361520060170060565
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Korean Journal of Psychopharmacology
2006 Volume.17 No. 6 p.565 ~ p.572
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The Effect of Fluoxetine on Behaviors in Transient Forebrain Ischemic Gerbil
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Li Hua
Kim Do-Hoon
Woo Moo-Ho
Um Hee-Jeong
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Abstract
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Objective： This study aims to explore the effect of fluoxetine on memory, locomotor and depressive behavior in transient forebrain ischemic model of gerbil.
Methods： Doses of fluoxetine (10, 40 ㎎/㎏) or vehicle were intraperitoneally administered once 30 min before ischemic surgery in gerbil. Novel object recognition test, spontaneous motor activity, learned helplessness test were performed 4 days, 8 days, or 9 days, respectively, after sham or ischemic surgery.
Results： Fluoxetine treatment (40 ㎎/㎏) significantly reduced recognition memory in sham operated gerbil. However, fluoxetine (10, 40 ㎎/㎏) did not affect ischemia-induced impairment in recognition memory. The treatment of fluoxetine (10, 40 ㎎/㎏) significantly inhibited locomotor hyperactivity induced by transient ischemia even though fluoxetine (40 ㎎/㎏) did not affect spontaneous motor activity in the sham operated gerbils. Fluoxetine did not affect depressive behavior in sham and ischemic gerbils.
Conclusion： The treatment of fluoxetine inhibited ischemia-induced hyperactivity, but did not affect memory and depressive behavior in transient forebrain ischemic gerbils.
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KEYWORD
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Transient forebrain ischemia, Fluoxetine, Novel object recognition test, Spontaneous motor activity, Learned helplessness test
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